The Schiff bases of pyridoxal-5-phosphate and hydrazides of certain pyrazoles: Stability, kinetics of formation, and synthesis


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Resumo

The interaction of pyridoxal-5-phosphate with 3-methyl-1Н-pyrazole-5-carbohydrazide, 2-(3,5-dimethyl-1Н-pyrazol-4-yl)acetohydrazide, and 1Н-pyrazole-3-carbohydrazide has yielded Schiff bases; the products have been characterized by 1Н NMR and IR spectra. The binding ability of these pyrazoles with respect to pyridoxal-5-phosphate under conditions modeling the living tissues has been evaluated. Rate constants of the formation of the Schiff bases have been determined.

Sobre autores

G. Gamov

Ivanovo State University of Chemistry and Technology

Autor responsável pela correspondência
Email: georgegamov38@gmail.com
Rússia, Sheremetevskii pr. 7, Ivanovo, 153000

V. Aleksandriiskii

Ivanovo State University of Chemistry and Technology; Krestov Institute of Solutions Chemistry

Email: georgegamov38@gmail.com
Rússia, Sheremetevskii pr. 7, Ivanovo, 153000; Ivanovo

M. Zavalishin

Ivanovo State University of Chemistry and Technology

Email: georgegamov38@gmail.com
Rússia, Sheremetevskii pr. 7, Ivanovo, 153000

A. Khokhlova

Ivanovo State University of Chemistry and Technology

Email: georgegamov38@gmail.com
Rússia, Sheremetevskii pr. 7, Ivanovo, 153000

V. Sharnin

Ivanovo State University of Chemistry and Technology; Krestov Institute of Solutions Chemistry

Email: georgegamov38@gmail.com
Rússia, Sheremetevskii pr. 7, Ivanovo, 153000; Ivanovo


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