1,3-oxazole derived cytisines

E. R. Abdurakhmanova; S. G. Pil’o; K. M. Kondratyuk; A. V. Golovchenko; V. S. Brovarets

doi:10.1134/S1070363217020153

1,3-oxazole derived cytisines

Autores: Abdurakhmanova E.R.¹, Pil’o S.G.¹, Kondratyuk K.M.¹, Golovchenko A.V.¹, Brovarets V.S.¹
Afiliações:
1. Institute of Bioorganic Chemistry and Petrochemistry
Edição: Volume 87, Nº 2 (2017)
Páginas: 244-251
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/218239
DOI: https://doi.org/10.1134/S1070363217020153
ID: 218239

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Reactions of 1-acylamino-2,2-dichloroacrylonitriles, diethyl 1-acylamino-2,2,2-trichloroethyl-phosphonates and 1-acylamino-2,2-dichloroethenylphosphonium salts with natural alkaloid cytisine have been studied. A series of novel multifunctional cytisine derivatives containing pharmacophore 1,3-oxazole moiety have been obtained. Composition and structure of the synthesized compounds have been confirmed by mass spectrometry and NMR spectroscopy data.