1,3-oxazole derived cytisines
- Authors: Abdurakhmanova E.R.1, Pil’o S.G.1, Kondratyuk K.M.1, Golovchenko A.V.1, Brovarets V.S.1
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Affiliations:
- Institute of Bioorganic Chemistry and Petrochemistry
- Issue: Vol 87, No 2 (2017)
- Pages: 244-251
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/218239
- DOI: https://doi.org/10.1134/S1070363217020153
- ID: 218239
Cite item
Abstract
Reactions of 1-acylamino-2,2-dichloroacrylonitriles, diethyl 1-acylamino-2,2,2-trichloroethyl-phosphonates and 1-acylamino-2,2-dichloroethenylphosphonium salts with natural alkaloid cytisine have been studied. A series of novel multifunctional cytisine derivatives containing pharmacophore 1,3-oxazole moiety have been obtained. Composition and structure of the synthesized compounds have been confirmed by mass spectrometry and NMR spectroscopy data.
About the authors
E. R. Abdurakhmanova
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
S. G. Pil’o
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
K. M. Kondratyuk
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
A. V. Golovchenko
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
V. S. Brovarets
Institute of Bioorganic Chemistry and Petrochemistry
Author for correspondence.
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660