Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms


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Resumo

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramolecular cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

Sobre autores

A. Erkin

St. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26

Email: kruerk@yandex.ru
Rússia, St. Petersburg, 190013

I. Klaptyuk

St. Petersburg University of State Fire Service at the Emergency Situations Ministry of Russian Federation

Email: kruerk@yandex.ru
Rússia, St. Petersburg

V. Gurzhii

St. Petersburg State University

Email: kruerk@yandex.ru
Rússia, St. Petersburg

O. Yuzikhin

Kirov St. Petersburg State Forest Technical University

Email: kruerk@yandex.ru
Rússia, St. Petersburg

V. Krutikov

St. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26

Autor responsável pela correspondência
Email: kruerk@yandex.ru
Rússia, St. Petersburg, 190013


Declaração de direitos autorais © Pleiades Publishing, Ltd., 2016

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