Medium Controlled Stoichiometric Complexation of Penicillin G—Potassium Drug with Se(IV), Nb(V), Ta(V), and Te(IV) Chlorides: Physicochemical and Antitumor Activity of the Complexes
- Авторлар: Aljuhani E.1
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Мекемелер:
- Department of Chemistry, Faculty of Applied Science
- Шығарылым: Том 89, № 5 (2019)
- Беттер: 1042-1050
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222921
- DOI: https://doi.org/10.1134/S1070363219050268
- ID: 222921
Дәйексөз келтіру
Аннотация
Four new 1: 1 ratio of Se+4, Nb+5, Ta+5, and Te+4 penicillinate complexes are synthesized in the reaction of penicillin potassium salt (Pin-G-K) with Se(IV), Nb(V), Ta(V), and Te(IV) chlorides. Structures of the synthesized complexes are characterized by elemental analysis, conductivity, magnetic susceptibility, IR, UV-Vis, 1H and 13C NMR, and mass spectra, SEM, TEM, and XRD. Diamagnetic and electronic spectral studies allow to elucidate the geometry of penicillinate chelates around central metal ions. The monomeric structures of Pin-G complexes with six or eight coordinated metal ions are proposed. The metal ions are coordinated toward Pin-G as tridentate chelates via the amide and β-lactam carbonyl, and monodentate carboxylate groups. According to powder XRD the complexes have crystalline to poly crystalline nature. In vitro antimicrobial activity of Pin-G complexes is tested against four bacteria pathogens: G− (Klebsiella and Escherichia coli) and G+ (Staphylococcus epidermidis and Staphylococcus aureus). Anti-tumor activity of the Pin-G complexes is assessed against human hepato cellular carcinoma (HepG-2) and human breast cancer (MCF-7) tumor cell lines.
Негізгі сөздер
Авторлар туралы
E. Aljuhani
Department of Chemistry, Faculty of Applied Science
Хат алмасуға жауапты Автор.
Email: dr.enas.aljuhani@gmail.com
Сауд Арабиясы, Makkah, 21955