Design, Synthesis, and Antimicrobial Activity of Novel 6-Oxopyrimidin-1(6H)-yl Benzamide Derivatives
- Авторлар: Devarasetty K.1, Vantikommu J.2, Anireddy J.2, Srinivas P.1
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Мекемелер:
- Chemistry Services Unit, GVK Biosciences Pvt. Ltd, IDA Nacharam
- Centre for Chemical Sciences and Technology
- Шығарылым: Том 89, № 4 (2019)
- Беттер: 780-788
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222870
- DOI: https://doi.org/10.1134/S1070363219040236
- ID: 222870
Дәйексөз келтіру
Аннотация
A series of novel 1-(benzamide)-N-cyclopropyl-2-(amino substituted)-6-oxo-1,6-dihydropyrimidine-5-carboxamide derivatives is synthesised and characterized by IR, 1H and 13C NMR, and mass spectra. The synthesized compounds 6a-6j and 8a-8j are screened for their in vitro antimicrobial activity against two Grampositive (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebesiella aerogenes), and two pathogenic fungi (Aspergillus flavus, Fusarium oxysporum). Most of the compounds demonstrate good to excellent antimicrobial activity in comparison with the standard drugs ciproflaxin and hymexazole. Among the screened compounds morpholine substituted dihydropyrimidone carboxamide 8j is determined to be the most potent anti-bacterial agent.
Авторлар туралы
K. Devarasetty
Chemistry Services Unit, GVK Biosciences Pvt. Ltd, IDA Nacharam
Email: srinivas.pusuluri18@gmail.com
Үндістан, Hyderabad, AP
J. Vantikommu
Centre for Chemical Sciences and Technology
Email: srinivas.pusuluri18@gmail.com
Үндістан, Hyderabad
J. Anireddy
Centre for Chemical Sciences and Technology
Email: srinivas.pusuluri18@gmail.com
Үндістан, Hyderabad
P. Srinivas
Chemistry Services Unit, GVK Biosciences Pvt. Ltd, IDA Nacharam
Хат алмасуға жауапты Автор.
Email: srinivas.pusuluri18@gmail.com
Үндістан, Hyderabad, AP