Design, Synthesis, and Antimicrobial Activity of Novel 6-Oxopyrimidin-1(6H)-yl Benzamide Derivatives
- Authors: Devarasetty K.1, Vantikommu J.2, Anireddy J.S.2, Srinivas P.1
-
Affiliations:
- Chemistry Services Unit, GVK Biosciences Pvt. Ltd, IDA Nacharam
- Centre for Chemical Sciences and Technology
- Issue: Vol 89, No 4 (2019)
- Pages: 780-788
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222870
- DOI: https://doi.org/10.1134/S1070363219040236
- ID: 222870
Cite item
Abstract
A series of novel 1-(benzamide)-N-cyclopropyl-2-(amino substituted)-6-oxo-1,6-dihydropyrimidine-5-carboxamide derivatives is synthesised and characterized by IR, 1H and 13C NMR, and mass spectra. The synthesized compounds 6a-6j and 8a-8j are screened for their in vitro antimicrobial activity against two Grampositive (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebesiella aerogenes), and two pathogenic fungi (Aspergillus flavus, Fusarium oxysporum). Most of the compounds demonstrate good to excellent antimicrobial activity in comparison with the standard drugs ciproflaxin and hymexazole. Among the screened compounds morpholine substituted dihydropyrimidone carboxamide 8j is determined to be the most potent anti-bacterial agent.
About the authors
K. Devarasetty
Chemistry Services Unit, GVK Biosciences Pvt. Ltd, IDA Nacharam
Email: srinivas.pusuluri18@gmail.com
India, Hyderabad, AP
J. Vantikommu
Centre for Chemical Sciences and Technology
Email: srinivas.pusuluri18@gmail.com
India, Hyderabad
J. Sh. Anireddy
Centre for Chemical Sciences and Technology
Email: srinivas.pusuluri18@gmail.com
India, Hyderabad
P. Srinivas
Chemistry Services Unit, GVK Biosciences Pvt. Ltd, IDA Nacharam
Author for correspondence.
Email: srinivas.pusuluri18@gmail.com
India, Hyderabad, AP