Мақаланы E-mail арқылы жіберу Synthesis and Anticancer Activity of Oxadiazole Incorporated Ellipticine Derivatives
- Авторлар: Sumalatha S.1,2, Namrata V.1, Lakshmi M.3, Sridhar G.4
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Мекемелер:
- Department of Chemistry
- Green Evolution Laboratories
- Department of Life Sciences
- Organic and Biomolecular Chemistry Division
- Шығарылым: Том 89, № 3 (2019)
- Беттер: 505-510
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222802
- DOI: https://doi.org/10.1134/S107036321903023X
- ID: 222802
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Аннотация
A series of ellipticine derivatives 8a–8j containing oxadiazole structural block are synthesized and evaluated for their anticancer activity on human cancer cell lines (Colo-205, MCF-7, A-549, and KB). Among those, the products 8b, 8c, 8d, 8i exhibit potent cytotoxic activity with GI50 values ranging from <0.1 to 23.6 µM. The positive control etoposide GI50 values are ranging from 0.13 to 3.08 µM.
Негізгі сөздер
Авторлар туралы
S. Sumalatha
Department of Chemistry; Green Evolution Laboratories
Email: sridhar1org@yahoo.com
Үндістан, Hyderabad, Telangana State, 500072; Wangapally Village, Nalgonda, Telangana State, 508286
V. Namrata
Department of Chemistry
Email: sridhar1org@yahoo.com
Үндістан, Karimnagar, Telangana State, 505002
M. Lakshmi
Department of Life Sciences
Email: sridhar1org@yahoo.com
Үндістан, Warangal, Telangana State, 506009
G. Sridhar
Organic and Biomolecular Chemistry Division
Хат алмасуға жауапты Автор.
Email: sridhar1org@yahoo.com
Үндістан, Hyderabad, 500107
