Synthesis of New Pyrazole Derivatives, Their Anti-Inflammatory and Analgesic Activities, and Molecular Docking Studies
- Авторлар: El Shehry M.1,2, Ewies E.3, Zayed E.4
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Мекемелер:
- Pesticide Chemistry Department
- Al-Zahrawi University College
- Organometallic and Organometalloid Chemistry Department
- Green Chemistry Department
- Шығарылым: Том 89, № 3 (2019)
- Беттер: 492-498
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222799
- DOI: https://doi.org/10.1134/S1070363219030216
- ID: 222799
Дәйексөз келтіру
Аннотация
A new series of coupled benzofuran derivatives that contain the trifluoromethyl group and pyrazole moiety is synthesized for evaluation of their anti-inflammatory and analgesic activities. Their synthesis proceeds via cyclocondensation of 2-hydroxy-4-(trifluoromethyl)benzaldehyde with chloroacetone with formation of 2-acetylbenzofuran, which upon treatment with different aldehydes via the Claisen-Schmidt condensation gives the corresponding chalcones. Cyclization of chalcones with hydrazine hydrate leads to pyrazoline derivatives, that exhibit significant anti-inflammatory and analgesic activities. Docking modelling of selected active compounds are correlated well with their anti-inflammatory tests data.
Негізгі сөздер
Авторлар туралы
M. El Shehry
Pesticide Chemistry Department; Al-Zahrawi University College
Email: ewiesfawzy@yahoo.com
Египет, Giza, 12622; Karbala
E. Ewies
Organometallic and Organometalloid Chemistry Department
Хат алмасуға жауапты Автор.
Email: ewiesfawzy@yahoo.com
Египет, Giza, 12622
E. Zayed
Green Chemistry Department
Email: ewiesfawzy@yahoo.com
Египет, 33 El-Bohouth St. (former El Tahrir St.), Dokki, Giza, 12622
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