Synthesis of New Pyrazole Derivatives, Their Anti-Inflammatory and Analgesic Activities, and Molecular Docking Studies
- Authors: El Shehry M.F.1,2, Ewies E.F.3, Zayed E.M.4
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Affiliations:
- Pesticide Chemistry Department
- Al-Zahrawi University College
- Organometallic and Organometalloid Chemistry Department
- Green Chemistry Department
- Issue: Vol 89, No 3 (2019)
- Pages: 492-498
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222799
- DOI: https://doi.org/10.1134/S1070363219030216
- ID: 222799
Cite item
Abstract
A new series of coupled benzofuran derivatives that contain the trifluoromethyl group and pyrazole moiety is synthesized for evaluation of their anti-inflammatory and analgesic activities. Their synthesis proceeds via cyclocondensation of 2-hydroxy-4-(trifluoromethyl)benzaldehyde with chloroacetone with formation of 2-acetylbenzofuran, which upon treatment with different aldehydes via the Claisen-Schmidt condensation gives the corresponding chalcones. Cyclization of chalcones with hydrazine hydrate leads to pyrazoline derivatives, that exhibit significant anti-inflammatory and analgesic activities. Docking modelling of selected active compounds are correlated well with their anti-inflammatory tests data.
Keywords
About the authors
M. F. El Shehry
Pesticide Chemistry Department; Al-Zahrawi University College
Email: ewiesfawzy@yahoo.com
Egypt, Giza, 12622; Karbala
E. F. Ewies
Organometallic and Organometalloid Chemistry Department
Author for correspondence.
Email: ewiesfawzy@yahoo.com
Egypt, Giza, 12622
E. M. Zayed
Green Chemistry Department
Email: ewiesfawzy@yahoo.com
Egypt, 33 El-Bohouth St. (former El Tahrir St.), Dokki, Giza, 12622