A Study on Hydrolytic Stability of Isatin N-Mannich Bases
- Авторлар: Orlova D.1, Novikova D.1, Garabadzhiu A.1, Tribulovich V.1
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Мекемелер:
- St. Petersburg State Institute of Technology (Technical University)
- Шығарылым: Том 88, № 1 (2018)
- Беттер: 48-56
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221941
- DOI: https://doi.org/10.1134/S1070363218010085
- ID: 221941
Дәйексөз келтіру
Аннотация
Stability parameters of biologically active compounds with N-Mannich base motif in their structure, which is susceptible to hydrolysis, have been studied. A procedure for the synthesis of small molecule compounds reactivating the function of the p53 tumor suppressor protein was developed, and the dependence of the Mannich base degradation rate on the structure of the compounds was established. For the hydrolysis reaction we determined the rate constants and calculated ρ, ΔG#, ΔH, and ΔS. Modifications of active compounds that retain the activity at the maximum possible stability were proposed.
Негізгі сөздер
Авторлар туралы
D. Orlova
St. Petersburg State Institute of Technology (Technical University)
Хат алмасуға жауапты Автор.
Email: orlova.daria.d@gmail.com
Ресей, Moskovskii pr. 26, St. Petersburg, 190013
D. Novikova
St. Petersburg State Institute of Technology (Technical University)
Email: orlova.daria.d@gmail.com
Ресей, Moskovskii pr. 26, St. Petersburg, 190013
A. Garabadzhiu
St. Petersburg State Institute of Technology (Technical University)
Email: orlova.daria.d@gmail.com
Ресей, Moskovskii pr. 26, St. Petersburg, 190013
V. Tribulovich
St. Petersburg State Institute of Technology (Technical University)
Email: orlova.daria.d@gmail.com
Ресей, Moskovskii pr. 26, St. Petersburg, 190013