Metal based sulfanilamides: A note on their synthesis, spectral characterization, and antimicrobial activity
- Авторлар: Rani S.1, Sumrra S.2, Chohan Z.2
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Мекемелер:
- Institute of Chemical Sciences
- Department of Chemistry
- Шығарылым: Том 87, № 8 (2017)
- Беттер: 1834-1842
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221118
- DOI: https://doi.org/10.1134/S107036321708031X
- ID: 221118
Дәйексөз келтіру
Аннотация
Objectives of the current study were synthesis, spectral characterization and biological screening of sulfanilamide derived Schiff bases and their metal based compounds. Sulfanilamide Schiff bases (L1–L3) were synthesized by condensation of 4-aminobenzenesulfanilamide with 1-(furan-2-yl)ethanone, 1-(thiophene-2-yl)-ethanone, and 1-acetylindoline-2,3-dione. The ligands were used for preparation of their Co(II), Ni(II), Cu(II), and Zn(II) complexes by using metals chlorides in metal: ligand (1: 2) molar ratio. All metal chelates had octahedral geometry with bidentate ligands. The ligands and their metal complexes were characterized by physical, spectral and analytical data, and screened for in-vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis) and for in vitro antifungal activity against six fungal pathogens (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glabrata). The results of antimicrobial studies revealed that the ligands activity was significantly increased upon chelation.
Негізгі сөздер
Авторлар туралы
S. Rani
Institute of Chemical Sciences
Email: sajjadchemist@gmail.com
Пәкістан, Multan, 60800
S. Sumrra
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: sajjadchemist@gmail.com
Пәкістан, Gujrat, 50700
Z. Chohan
Department of Chemistry
Email: sajjadchemist@gmail.com
Пәкістан, Bhakkar Campus, Sargodha