Co(II) and Ni(II) complexes with Schiff base ligands: Synthesis, characterization, and biological activity
- Авторлар: Gupta B.1, Fahmi N.1
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Мекемелер:
- Department of Chemistry
- Шығарылым: Том 86, № 5 (2016)
- Беттер: 1182-1190
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215136
- DOI: https://doi.org/10.1134/S1070363216050339
- ID: 215136
Дәйексөз келтіру
Аннотация
The ligands, 1-acetylferrocenehydrazinecarboxamide (HL1) and 1-acetylferrocenehydrazinecarbothioamide (HL2), and their Ni(II) and Co(II) complexes were synthesized. The properties of the synthesized compounds were determined by the elemental and spectroscopic analyses. Ni(II) and Co(II) acetates interact with the ligands at the molar ratios 1 : 1 and 1 : 2 to give coloured products. The complexes have octahedral geometry. The ligands are coordinated to Co(II) and Ni(II) centers via the azomethine nitrogen and thiolic sulfur /enolic oxygen atom. The ligands and their Co(II) and Ni(II) complexes were screened for antibacterial and antifungal activities. The Co(II) and Ni(II) complexes show enhanced inhibitory activity as compared to their parent ligands. The DNA cleavage activity of the Co(II) and Ni(II) complexes was determined by gel electrophoresis. It was shown that the complexes have better cleavage activity than the ligands. The antioxidant activity of the complexes was also evaluated and used to examine their scavenging ability on hydrogen peroxide.
Авторлар туралы
B. Gupta
Department of Chemistry
Email: bhanu2514@gmail.com
Үндістан, Jaipur, 302004
N. Fahmi
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: bhanu2514@gmail.com
Үндістан, Jaipur, 302004