Synthesis and Properties of C,N-Chelated Carbene Complexes of Palladium(II) with 2-Aminobenzo[d]thiazole Fragment
- Authors: Mikherdov A.S.1, Baikov S.V.1, Proskurina I.K.2, Shetnev A.A.2, Kotov A.D.2
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Affiliations:
- St. Petersburg State University
- M. Dorogov Center for the Transfer of Pharmaceutical Technologies
- Issue: Vol 89, No 10 (2019)
- Pages: 2062-2068
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223116
- DOI: https://doi.org/10.1134/S1070363219100128
- ID: 223116
Cite item
Abstract
The reaction of bis(cyclohexylisocyanide) complex of Pd(II) with substituted benzo[d]thiazole-2-amines in the presence of triethanolamine as the base has lead to the formation of deprotonated C,N-chelated carbene complexes with a structure similar to that described previously for the products of the reaction with unsubstituted benzo[d]thiazole-2-amine. The complexes have been isolated and characterized using high-resolution mass spectrometry, IR and NMR spectroscopy (1H, 13C{1H}, 1H-1H COSY, 1H-1H NOESY, 1H-13C HSQC, 1H-13C HMBC). The resulting complexes have exhibited moderate antibacterial activity against sensitive strains of gram-negative bacteria E. coli (C600) and P. fluorescens (P218), gram-positive bacteria S. aureus (ATCC-25923) and B. subtillis (B-3142D) as well as fungi C. albicans (401/NCTC-885-653).
About the authors
A. S. Mikherdov
St. Petersburg State University
Author for correspondence.
Email: asm93@yandex.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
S. V. Baikov
St. Petersburg State University
Email: asm93@yandex.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
I. K. Proskurina
M. Dorogov Center for the Transfer of Pharmaceutical Technologies
Email: asm93@yandex.ru
Russian Federation, Yaroslavl
A. A. Shetnev
M. Dorogov Center for the Transfer of Pharmaceutical Technologies
Email: asm93@yandex.ru
Russian Federation, Yaroslavl
A. D. Kotov
M. Dorogov Center for the Transfer of Pharmaceutical Technologies
Email: asm93@yandex.ru
Russian Federation, Yaroslavl