Synthesis, Spectroscopy, and Anticancer Activity of Two New Nanoscale Au(III) N4 Schiff Base Complexes
- Authors: Naglah A.M.1,2, Al-Omar M.A.1, Kalmouch A.2, Gobouri A.A.3, Abdel-Hafez S.H.3, El-Megharbel S.M.3, Refat M.S.3,4
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Affiliations:
- Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy
- Peptide Chemistry Department, Chemical Industries Research Division
- Chemistry Department, Faculty of Science
- Department of Chemistry, Faculty of Science
- Issue: Vol 89, No 8 (2019)
- Pages: 1702-1706
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223049
- DOI: https://doi.org/10.1134/S1070363219080255
- ID: 223049
Cite item
Abstract
Mononuclear Au(III) Schiff base complexes are synthesized by the reaction of 4-aminoantipyrine with hydrazine. The chemical structures of new Schiff bases and their Au(III) complexes are elucidated from their conductance, XRD, and spectroscopic (IR, UV-Vis, 1H, and 13C NMR) data. Au(III) Ion is coordinated with the synthesized Schiff bases via four nitrogen atoms of the antipyrine and azomethine groups. Au(III) Complexes are electrolytes with three uncoordinated Cl− ions, and have a square planar geometry. Their morphology is characterized by SEM and TEM methods. Cytotoxic effect of the complexes is tested against human breast cancer (MCF-7) and hepatocellular carcinoma (HepG-2) cell lines.
Keywords
About the authors
A. M. Naglah
Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy; Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
M. A. Al-Omar
Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451
A. Kalmouch
Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Egypt, Dokki, Cairo, 12622
A. A. Gobouri
Chemistry Department, Faculty of Science
Email: msrefat@yahoo.com
Saudi Arabia, Al-Hawiah, Taif, 21974
S. H. Abdel-Hafez
Chemistry Department, Faculty of Science; Chemistry Department, Faculty of Science
Email: msrefat@yahoo.com
Saudi Arabia, Al-Hawiah, Taif, 21974; Assiut, 71516
S. M. El-Megharbel
Chemistry Department, Faculty of Science; Chemistry Department, Faculty of Science
Email: msrefat@yahoo.com
Saudi Arabia, Al-Hawiah, Taif, 21974; Zagazig, 44519
M. S. Refat
Chemistry Department, Faculty of Science; Department of Chemistry, Faculty of Science
Author for correspondence.
Email: msrefat@yahoo.com
Saudi Arabia, Al-Hawiah, Taif, 21974; Port Said