Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile
- Authors: Islamova R.M.1, Suslonov V.V.2, Demakova M.Y.1
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Affiliations:
- St. Petersburg State University
- Center for X-Ray Diffraction Studies
- Issue: Vol 89, No 4 (2019)
- Pages: 668-672
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222847
- DOI: https://doi.org/10.1134/S1070363219040054
- ID: 222847
Cite item
Abstract
4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.
About the authors
R. M. Islamova
St. Petersburg State University
Email: st008217@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
V. V. Suslonov
Center for X-Ray Diffraction Studies
Email: st008217@spbu.ru
Russian Federation, St. Petersburg
M. Ya. Demakova
St. Petersburg State University
Author for correspondence.
Email: st008217@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034