Selective Complexation of Hydrazone Based Ketimine with 3d, 4d, and 5d Metals: Synthesis, Characterization, and Biological Activity
- Authors: Ahmad F.1, Taj M.B.1, Tirmizi S.A.1, Alelwani W.2, Hajjar D.2, Makki A.A.2, Shah S.1, Ali U.1, Hassan U.1, Tahir M.1, Siddiq S.3
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Affiliations:
- Department of Chemistry
- Department of Biochemistry, Faculty of Science
- HEJ Research Institute Karachi
- Issue: Vol 89, No 1 (2019)
- Pages: 142-147
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222723
- DOI: https://doi.org/10.1134/S1070363219010250
- ID: 222723
Cite item
Abstract
The hydrazone derived ketimine of dehydroacetic acid and its metal {Cu(II), Ni(II), Zn(II), Fe(III), Cd(II), Pd(II), La(III), Nd(III), Ce(III)} complexes are synthesized and characterized by IR, 1H and 13C NMR, and UV-Vis spectroscopy. DNA studies have been carried out for metal complexes by electronic absorption spectroscopy. It is determined that metal complexes bind to DNA through intercalation. The complexes of Cu(II), Zn(II) and Pd(II) demonstrate significant activity against HeLa cells (cervical cancer).
About the authors
F. Ahmad
Department of Chemistry
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 44000
M. B. Taj
Department of Chemistry
Author for correspondence.
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 63100
S. A. Tirmizi
Department of Chemistry
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 44000
W. Alelwani
Department of Biochemistry, Faculty of Science
Email: drbabartaj@gmail.com
Pakistan, Saudi Arabia, 80203
D. Hajjar
Department of Biochemistry, Faculty of Science
Email: drbabartaj@gmail.com
Pakistan, Saudi Arabia, 80203
A. A. Makki
Department of Biochemistry, Faculty of Science
Email: drbabartaj@gmail.com
Pakistan, Saudi Arabia, 80203
S. Shah
Department of Chemistry
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 44000
U. Ali
Department of Chemistry
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 44000
U. Hassan
Department of Chemistry
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 44000
M. Tahir
Department of Chemistry
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 44000
S. Siddiq
HEJ Research Institute Karachi
Email: drbabartaj@gmail.com
Pakistan, Islamabad, 75270