Synthesis, Antimicrobial, and Antioxidant Studies of Some New Indolo[3,2-c]isoquinoline Derivatives
- Authors: Verma V.A.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 88, No 12 (2018)
- Pages: 2628-2645
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222608
- DOI: https://doi.org/10.1134/S1070363218120265
- ID: 222608
Cite item
Abstract
As a part of systematic study, new series of 6-{[5-(5-substituted 2-phenyl-1H-indol-3-yl)- methyleneamino]-1,3,4-oxadiazol-2-yl}-8-substituted-6H-indolo[3,2-c]isoquinolin-5(11H)-ones and their derivatives are synthesized and evaluated for their biological activities. Compound 8a displays potent antimicrobial activity against bacteria E. coli, K. penumoniae, and S. aureus, and fungi A. niger, A. flavus, and A. fumigates. Compounds 7a and 8a demonstrate promising radical scavenging and chelating with ferrous ions (Fe2+). According to the accumulated data the designed motifs exhibit higher biological activities than the reference compounds.
About the authors
Vaijinath A. Verma
Department of Chemistry
Author for correspondence.
Email: drvermachem@gmail.com
India, Shahabad, Kalaburagi, Karnataka, 585228