Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives
- Authors: Popova E.A.1, Mikolaichuk O.V.1, Protas A.V.1, Mukhametshina A.V.1, Ovsepyan G.K.1, Starova G.L.1, Suezov R.V.2,3, Fonin A.V.3, Trifonov R.E.1,2
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Affiliations:
- St. Petersburg State University
- St. Petersburg State Institute of Technology
- Institute of Cytology
- Issue: Vol 88, No 11 (2018)
- Pages: 2354-2358
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222540
- DOI: https://doi.org/10.1134/S1070363218110178
- ID: 222540
Cite item
Abstract
A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–{1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.
About the authors
E. A. Popova
St. Petersburg State University
Author for correspondence.
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
O. V. Mikolaichuk
St. Petersburg State University
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
A. V. Protas
St. Petersburg State University
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
A. V. Mukhametshina
St. Petersburg State University
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
G. K. Ovsepyan
St. Petersburg State University
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
G. L. Starova
St. Petersburg State University
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034
R. V. Suezov
St. Petersburg State Institute of Technology; Institute of Cytology
Email: elena.popova@spbu.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013; Tikhoretskii pr. 4, St. Petersburg, 194064
A. V. Fonin
Institute of Cytology
Email: elena.popova@spbu.ru
Russian Federation, Tikhoretskii pr. 4, St. Petersburg, 194064
R. E. Trifonov
St. Petersburg State University; St. Petersburg State Institute of Technology
Email: elena.popova@spbu.ru
Russian Federation, Universitetskaya nab. 7–9, St. Petersburg, 199034; Moskovskii pr. 26, St. Petersburg, 190013