Synthesis, Structure, and Antiproliferative Activity of  trans -Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives

E. A. Popova; O. V. Mikolaichuk; A. V. Protas; A. V. Mukhametshina; G. K. Ovsepyan; G. L. Starova; R. V. Suezov; A. V. Fonin; R. E. Trifonov

doi:10.1134/S1070363218110178

Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives

Authors: Popova E.A.¹, Mikolaichuk O.V.¹, Protas A.V.¹, Mukhametshina A.V.¹, Ovsepyan G.K.¹, Starova G.L.¹, Suezov R.V.²^,3, Fonin A.V.³, Trifonov R.E.¹^,2
Affiliations:
1. St. Petersburg State University
2. St. Petersburg State Institute of Technology
3. Institute of Cytology
Issue: Vol 88, No 11 (2018)
Pages: 2354-2358
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222540
DOI: https://doi.org/10.1134/S1070363218110178
ID: 222540

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Abstract

A series of trans-palladium(II) complexes (trans-[PdCl₂L₂], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by ¹H and ¹³C–{¹H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.