Synthesis, Characterization, Computational, Antimicrobial Screening, and MTT Assay of Thiazolidinone Derivatives Containing the Indole and Pyridine Moieties
- Authors: Arshad M.1, Shoeb Khan M.2, Asghar Nami S.A.3, Ahmad D.4
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Affiliations:
- Department of Basic Sciences, College of Medicine, Al Dawadmi
- Interdisciplinary Nanotechnology Centre
- Department of Kulliyat, Faculty of Unani Medicine
- College of Pharmacy, Al-Dawadmi
- Issue: Vol 88, No 10 (2018)
- Pages: 2154-2162
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222491
- DOI: https://doi.org/10.1134/S1070363218100213
- ID: 222491
Cite item
Abstract
A series of novel 2-{[1-(arenesulfonyl)-1H-indol-3-yl]-4-oxo-1,3-thiazolidin-3-yl}pyridine-4-carboxamide derivatives was designed and calculate for their computational properties like physicochemical parameters and bioactivity score. Bioactive compounds 1–8, were then synthesized, Characterized by various spercoscopic techniques and assessed for antibacterial activity against S. aureus, S. epidermidis, P. mirabilis, and E. coli. The percent viability of the cells was carried out by MTT assay using HepG2 cells. The results for antibacterial activity were observed in strong recommendation with the computation results. The synthesized compounds were found to portray better activity and lower cytotoxicity when compared to the standard drug Ciprofloxacin.
About the authors
M. Arshad
Department of Basic Sciences, College of Medicine, Al Dawadmi
Author for correspondence.
Email: mohdarshad1985@gmail.com
Saudi Arabia, Shaqra, 11911
M. Shoeb Khan
Interdisciplinary Nanotechnology Centre
Email: mohdarshad1985@gmail.com
India, Aligarh
S. A. Asghar Nami
Department of Kulliyat, Faculty of Unani Medicine
Email: mohdarshad1985@gmail.com
India, Aligarh
D. Ahmad
College of Pharmacy, Al-Dawadmi
Email: mohdarshad1985@gmail.com
Saudi Arabia, Shaqra