Synthesis of Amphiphilic Oligomers of Acrylic Acid
- Authors: Korshak Y.V.1, Mezhuev Y.O.1, Sizova O.Y.1, Luss A.L.1, Shtilman M.I.1
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Affiliations:
- Mendeleev University of Chemical Technology of Russia
- Issue: Vol 88, No 10 (2018)
- Pages: 2144-2148
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222488
- DOI: https://doi.org/10.1134/S1070363218100195
- ID: 222488
Cite item
Abstract
Synthesis of amphiphilic oligomers of acrylic acid via radical polymerization in the presence of thiols as molecular mass regulators is described. The effect of the length of the introduced hydrophobic terminal group on the critical micellization concentration of the acrylic acid oligomers has been elucidated. It has been shown that the incorporation of an antituberculous drug (prothionamide) in the micelles of acrylic acid oligomers is enhanced with the increase in the length of the hydrophobic moiety. The preparation of hydroxyapatite-filled calcium-polycarboxylate bone cements containing prothionamide (promising for the sealing of postoperative cavities) is described.
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About the authors
Yu. V. Korshak
Mendeleev University of Chemical Technology of Russia
Email: valsorja@mail.ru
Russian Federation, Miusskaya pl. 9, Moscow, 125047
Ya. O. Mezhuev
Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: valsorja@mail.ru
Russian Federation, Miusskaya pl. 9, Moscow, 125047
O. Yu. Sizova
Mendeleev University of Chemical Technology of Russia
Email: valsorja@mail.ru
Russian Federation, Miusskaya pl. 9, Moscow, 125047
A. L. Luss
Mendeleev University of Chemical Technology of Russia
Email: valsorja@mail.ru
Russian Federation, Miusskaya pl. 9, Moscow, 125047
M. I. Shtilman
Mendeleev University of Chemical Technology of Russia
Email: valsorja@mail.ru
Russian Federation, Miusskaya pl. 9, Moscow, 125047