Synthesis and Structure of 2-(4-Heteryl-2-pyrrolidon-1-yl)acetamides

O. S. Vasil’eva; E. S. Ostroglyadov; N. V. Gorodnicheva; S. V. Makarenko; I. N. Tyurenkov; V. N. Perfilova; S. M. Aleksandrova

doi:10.1134/S1070363218070046

Synthesis and Structure of 2-(4-Heteryl-2-pyrrolidon-1-yl)acetamides

Authors: Vasil’eva O.S.¹, Ostroglyadov E.S.², Gorodnicheva N.V.¹, Makarenko S.V.¹, Tyurenkov I.N.², Perfilova V.N.², Aleksandrova S.M.³
Affiliations:
1. Herzen State Pedagogical University of Russia
2. Volgograd State Medical University
3. Pskov State University
Issue: Vol 88, No 7 (2018)
Pages: 1374-1380
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222303
DOI: https://doi.org/10.1134/S1070363218070046
ID: 222303

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Abstract

1-Alkoxycarbonylmethyl-4-heteryl-2-pyrrolidones were synthesized by alkylation of 4-heteryl-2-pyrrolidones. 2-(4-Heteryl-2-pyrrolidon-1-yl)acetamides were prepared through the reaction of N-esters with ammonia. The resulting acetamides of 2-pyrrolidones exhibit nootropic properties, antiarrhythmic and antiischemic activity.