p-Aromatic Isothiocyanates: Synthesis and Anti Plant Pathogen Activity
- Authors: Tang J.1, Niu J.1, Wang W.1, Huo H.1, Li J.1, Luo L.1, Cao Y.1
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Affiliations:
- College of Plant Protection
- Issue: Vol 88, No 6 (2018)
- Pages: 1252-1257
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222273
- DOI: https://doi.org/10.1134/S1070363218060348
- ID: 222273
Cite item
Abstract
In this study, a series of p-aromatic isothiocyanates are prepared by reacting p-aromatic amines with carbon disulphide and further treating with molecular iodine to yield corresponding isothiocyanate derivatives. The structures of newly synthesized compounds are confirmed by IR, NMR, and MS data. Activity of the products against plant pathogenic fungi and bacteria is tested and the structure-activity relationship is approached. p-Nitrophenyl isothiocyanate most efficiently inhibits Rhizoctonia solani and Erwinia carotovora. The order of seven aromatic isothiocyanates antifungicidal activity is following: p-nitrophenyl > p-methoxyphenyl > p-chlorophenyl > p-methylphenyl > p-ethylphenyl > phenyl > p-fluorophenyl. For antibacterial activity, the order was p-nitrophenyl > p-chlorophenyl > p-methylphenyl > p-ethylphenyl > p-fluorophenyl > phenyl > p-methoxyphenyl. The present study indicates that some of the compounds exhibit promising antimicrobial activity and can be used as an alternative to the traditional synthetic fungicides for controlling R. solani and E. carotovora.
About the authors
J. Tang
College of Plant Protection
Email: caoysong@126.com
China, Beijing, 100193
J. Niu
College of Plant Protection
Email: caoysong@126.com
China, Beijing, 100193
W. Wang
College of Plant Protection
Email: caoysong@126.com
China, Beijing, 100193
H. Huo
College of Plant Protection
Email: caoysong@126.com
China, Beijing, 100193
J. Li
College of Plant Protection
Email: caoysong@126.com
China, Beijing, 100193
L. Luo
College of Plant Protection
Email: caoysong@126.com
China, Beijing, 100193
Y. Cao
College of Plant Protection
Author for correspondence.
Email: caoysong@126.com
China, Beijing, 100193