Email this article Synthesis and Study on the Potential Anticancer Activity of Phosphinolinium-Type Halide Salts
- Authors: Prokofieva D.S.1, Abzianidze V.V.2, Bogachenkov A.S.3,4
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Affiliations:
- ZAO “Institute of Experimental Pharmacology”
- Chemical Modeling Laboratory, Research Institute of Hygiene, Occupational Pathology and Human Ecology
- Department of Organic Chemistry, Institute of Chemistry
- Department of Organic Chemistry
- Issue: Vol 87, No 12 (2017)
- Pages: 2989-2994
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221806
- DOI: https://doi.org/10.1134/S107036321712043X
- ID: 221806
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Abstract
Cytotoxic activity of the newly synthesized phosphinolinium-type bromide salts was evaluated against two cell lines of human origin: A549 lung adenocarcinoma and U251 glioblastoma using the sulforhodamine B assay. Compound with long alkyl chain demonstrate a stronger effect on viability of two cell lines than cysplatin.
About the authors
D. S. Prokofieva
ZAO “Institute of Experimental Pharmacology”
Email: alexterve@gmail.com
Russian Federation, p/o Kuz’molovskii, str. 245, St. Petersburg, 188663
V. V. Abzianidze
Chemical Modeling Laboratory, Research Institute of Hygiene, Occupational Pathology and Human Ecology
Email: alexterve@gmail.com
Russian Federation, p/o Kuz’molovskii, St. Petersburg, 188663
A. S. Bogachenkov
Department of Organic Chemistry, Institute of Chemistry; Department of Organic Chemistry
Author for correspondence.
Email: alexterve@gmail.com
Russian Federation, Universitetskii pr. 26, St. Petersburg, 198504; Moskovskii pr. 26, St. Petersburg, 190013
