Synthesis and characterization of novel pyran and pyranopyrimidines linked 8-hydroxy-7-iodoquinoline-5-sulfonamide derivatives
- Authors: Al-Omar M.A.1, Khalifa N.M.1,2, Amr A.E.1,3
-
Affiliations:
- Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
- Therapeutically Chemistry Department, Pharmaceutical and Drug Industries Division
- Applied Organic Chemistry Department
- Issue: Vol 87, No 10 (2017)
- Pages: 2467-2471
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221510
- DOI: https://doi.org/10.1134/S1070363217100309
- ID: 221510
Cite item
Abstract
Several novel 8-hydroxy-7-iodoquinoline-5-sulfonamides bearing pyran and pyrano[2,3-d]pyrimidine derivatives were synthesized via a one-pot base catalyzed cyclocondensation reaction of N-(4-acetylphenyl)-8-hydroxy-7-iodoquinoline-5-sulfonamide with malononitrile and arylaldehydes, followed by heterocyclization of the resulting intermediates with the appropriate reagents such as carbon disulphide, formic acid, thiourea, and formamide.
About the authors
M. A. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451
N. M. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Therapeutically Chemistry Department, Pharmaceutical and Drug Industries Division
Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
A. E. Amr
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Applied Organic Chemistry Department
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622