Synthesis, characterization, and biological activity of organotin(IV) complexes with 4-oxo-4-[3-(trifluoromethyl)phenylamino]butanoic acid
- Authors: Javed F.1,2, Ali S.1, Shahzadi S.1, Sharma S.K.3, Qanungo K.3, Munawar K.S.1, Khan I.4
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Affiliations:
- Department of Chemistry
- School of Materials and Mineral Resources Engineering, Engineering Campus
- Department of Applied Sciences and Human Services, Faculty of Engineering and Technology
- Department of Biotechnology
- Issue: Vol 87, No 10 (2017)
- Pages: 2409-2420
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221461
- DOI: https://doi.org/10.1134/S1070363217100231
- ID: 221461
Cite item
Abstract
Metal complexes display functional interfaces for association with and stimulation of certain enzymes, that are liable to transfer genetic information in DNA for synthesis of specific proteins. Biological activity of five organotin carboxylates based on the ligand, 4-oxo-4-[3-(trifluoromethyl)phenylamino]butanoic acid, such as [Bu3SnL] (1), [Ph3SnL] (2), [Me2SnL2] (3), [Bu2SnL2] (4), and [Ph2SnL2] (5) have been synthesized and their biological activity as a function of substitution on the ligand was tested. Structure of the complexes was evaluated by elemental analysis, FT-IR and 1H, and 13C NMR spectra. FT-IR data and theoretical calculations revieled that the ligand acted as bidentate in complexes 1–5. NMR data revealed four and six coordinated geometry of tin in solutions. The HOMO–LUMO study indicated thermodynamic stability of the complexes. AFM confirmed catalytic potential of the synthesized complexes. Biological screening showed that, with few exceptions, all the complexes exhibited significant activity against various bacterial and fungal strains. UV-Vis study confirmed that the ligand and its complexes binded to DNA via intercalative interactions.
About the authors
F. Javed
Department of Chemistry; School of Materials and Mineral Resources Engineering, Engineering Campus
Author for correspondence.
Email: fatimajaved@ymail.com
Pakistan, Islamabad, 45320; Nibong Tebal, Pulau Pinang, 14300
S. Ali
Department of Chemistry
Author for correspondence.
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
S. Shahzadi
Department of Chemistry; Department of Chemistry
Author for correspondence.
Email: sairashahzadi@hotmail.com
Pakistan, Islamabad, 45320; Faisalabad
S. K. Sharma
Department of Applied Sciences and Human Services, Faculty of Engineering and Technology
Email: sairashahzadi@hotmail.com
India, Lakshmangargh, Dist Sikar, Raj, 332311
K. Qanungo
Department of Applied Sciences and Human Services, Faculty of Engineering and Technology
Email: sairashahzadi@hotmail.com
India, Lakshmangargh, Dist Sikar, Raj, 332311
K. S. Munawar
Department of Chemistry
Email: sairashahzadi@hotmail.com
Pakistan, Sargodha
I. Khan
Department of Biotechnology
Email: sairashahzadi@hotmail.com
Pakistan, Islamabad, 45320