Complexes of Cu(I) and Pd(II) with (+)-camphor and (–)-cavrone thiosemicarbazones: Synthesis, structure, and cytotoxicity of the Pd(II) complex
- Authors: Kokina T.E.1,2, Sheludyakova L.A.1,2, Eremina Y.A.1,2, Vorontsova E.V.3, Glinskaya L.A.1, Piryazev D.A.1,2, Lider E.V.1,2, Tkachev A.V.2,4, Larionov S.V.1,2
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Affiliations:
- Nikolaev Institute of Inorganic Chemistry, Siberian Branch
- Novosibirsk State University
- Research Institute of Molecular Biology and Biophysics, Siberian Branch
- Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Issue: Vol 87, No 10 (2017)
- Pages: 2332-2342
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221417
- DOI: https://doi.org/10.1134/S1070363217100140
- ID: 221417
Cite item
Abstract
CuLCl, CuL1Cl, PdLCl2, and PdL1Cl2 complexes [L and L1 being (+)-camphor and (–)-carvone thiosemicarbazones, respectively] have been synthesized. The structure of binuclear [Pd2L22Cl4] complex has been determined by means of X-ray diffraction. The L2 ligand (dehydrogenated (–)-carvone thiosemicarbazone) is coordinated via the bridging S atom to two Pd atoms. The complexes of Cu(I) and Pd(II) presumably have polynuclear and binuclear structure, respectively. These facts are in good agreement with IR and NMR spectroscopy as well as mass spectrometry data which indicate the coordination of L and L1 ligands via the S atom. The influence of L1 and PdL1Cl2 on viability of the Hep2 cell line has been studied. The PdL1Cl2 complex is more cytotoxic than L1 ligand.
Keywords
About the authors
T. E. Kokina
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Author for correspondence.
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090; Novosibirsk
L. A. Sheludyakova
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090; Novosibirsk
Yu. A. Eremina
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090; Novosibirsk
E. V. Vorontsova
Research Institute of Molecular Biology and Biophysics, Siberian Branch
Email: kokina@niic.nsc.ru
Russian Federation, Novosibirsk
L. A. Glinskaya
Nikolaev Institute of Inorganic Chemistry, Siberian Branch
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090
D. A. Piryazev
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090; Novosibirsk
E. V. Lider
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090; Novosibirsk
A. V. Tkachev
Novosibirsk State University; Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: kokina@niic.nsc.ru
Russian Federation, Novosibirsk; Novosibirsk
S. V. Larionov
Nikolaev Institute of Inorganic Chemistry, Siberian Branch; Novosibirsk State University
Email: kokina@niic.nsc.ru
Russian Federation, pr. Akademica Lavrent’eva 3, Novosibirsk, 630090; Novosibirsk