NO2-Fe(III)PcCl@C -catalyzed one-pot synthesis of tetrahydropyridine derivatives


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Abstract

A highly efficient, one-pot synthesis of functionalized tetrahydropyridines by multicomponent condensation of ethyl acetoacetate, two equivalents of aromatic aldehyde, and aromatic amine in the presence of a catalytic amount of NO2-Fe(III)PcCl@C is reported. In this way, a series of pharmacologically interesting substituted pyridine derivatives were obtained in moderate to good yields.

About the authors

Jiao-dan Wang

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069

Qiao-li Lin

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069

Jun Qiu

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069

Xiao-feng Gou

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069

Cheng-wen Hua

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069

Jun-long Zhao

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069

Bang Chen

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science

Author for correspondence.
Email: chenbang@china.com.cn
China, Shaanxi, Xi’an 710069


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