Biological evaluation of 4-aryl-1,4-dihydropyridines as VEGFR-2 kinase inhibitors
- Authors: Sun W.1, Ma Z.1, Yan H.1
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Affiliations:
- College of Life Science and Bioengineering
- Issue: Vol 86, No 12 (2016)
- Pages: 2891-2899
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217319
- DOI: https://doi.org/10.1134/S1070363216120574
- ID: 217319
Cite item
Abstract
Vascular endothelial growth factor-2 receptor (VEGFR-2) kinase is a promising target for the development of novel anticancer drugs. Molecular docking modeling was performed on a series of 4-aryl-1,4-dihydropyridines derivatives to evaluate the structural basis for VEGFR-2 inhibitory activity. Some 4-aryl-1,4-dihydropyridines were synthesized in the reaction of aromatic aldehydes and ethyl propiolate with anilines in acetic acid. The biological activities were evaluated against the cells A549, A431 and Hep-G2. The results indicated that 4-aryl-1,4-dihydropyridines could be the promising potential VEGFR-2 inhibitors.
About the authors
W. Sun
College of Life Science and Bioengineering
Email: hongyan@bjut.edu.cn
China, Pingleyuan no. 100 of Chaoyang District, Beijing, 100124
Z. Ma
College of Life Science and Bioengineering
Email: hongyan@bjut.edu.cn
China, Pingleyuan no. 100 of Chaoyang District, Beijing, 100124
H. Yan
College of Life Science and Bioengineering
Author for correspondence.
Email: hongyan@bjut.edu.cn
China, Pingleyuan no. 100 of Chaoyang District, Beijing, 100124