Nano isopolyoxomolybdate catalyzed Biginelli reaction for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones under solvent-free conditions
- Authors: Nakhaei A.1, Davoodnia A.2, Yadegarian S.1
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Affiliations:
- Young Researchers and Elite Club, Mashhad Branch
- Department of Chemistry, Mashhad Branch
- Issue: Vol 86, No 12 (2016)
- Pages: 2870-2876
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217142
- DOI: https://doi.org/10.1134/S1070363216120537
- ID: 217142
Cite item
Abstract
The Biginelli reaction of β-ketoesters with aryl aldehyde and urea or thiourea in the presence of a Keplerate type giant nanoporous isopolyoxomolybdate, (NH4)42[Mo72VIMo60VO372(CH3COO)30(H2O)72], presented as {Mo132}, as an efficient catalyst under solvent free conditions is reported. The catalyst was synthesized according to the earlier published procedure using inexpensive and readily available starting materials. The catalyst could be recovered and reused efficiently in six cycles. Other beneficial features of this new synthetic approach include short reaction time, high yields, clean reaction profiles, and a simple work-up procedure.
About the authors
A. Nakhaei
Young Researchers and Elite Club, Mashhad Branch
Author for correspondence.
Email: nakhaei_a@yahoo.com
Iran, Islamic Republic of, Mashhad
A. Davoodnia
Department of Chemistry, Mashhad Branch
Email: nakhaei_a@yahoo.com
Iran, Islamic Republic of, Mashhad
S. Yadegarian
Young Researchers and Elite Club, Mashhad Branch
Email: nakhaei_a@yahoo.com
Iran, Islamic Republic of, Mashhad