Synthesis of some new 5-(1-phenyl-1H-1,2,3-triazol-4-yl)-1H-tetrazoles and evaluation of their antimicrobial activity
- Authors: Naresh E.1, Bhaskar K.1, Linga goud G.1
-
Affiliations:
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Issue: Vol 86, No 12 (2016)
- Pages: 2862-2864
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217071
- DOI: https://doi.org/10.1134/S1070363216120513
- ID: 217071
Cite item
Abstract
a series of new tetrazole derivatives were synthesized by a reaction of triazole oxime with sodium azide catalyzed by copper acetate and isolated with high yield under mild conditions. All synthesized compounds were characterized by IR, NMR, and MS data. Evaluation of antimicrobial activity of the products against Gram-positive and Gram-negative bacterial and antifungal strains has been carried out. Among the compounds 3a, 3c, 3e, and 3f exhibited high antibacterial activity and compounds 3a, 3c, 3e demonstrated high antifungal activity.
About the authors
E. Naresh
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Author for correspondence.
Email: ellendula.naresh@gmail.com
India, Hyderabad, 500007
K. Bhaskar
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ellendula.naresh@gmail.com
India, Hyderabad, 500007
G. Linga goud
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ellendula.naresh@gmail.com
India, Hyderabad, 500007
![](/img/style/loading.gif)