Email this article Synthesis, characterization, and antimicrobial activity of some chiral linear carboxamides with incorporated peptide linkage
- Authors: Khalifa N.M.1,2, Amr A.E.1,3, Al-Omar M.A.1, Nossier E.S.4
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Affiliations:
- Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy
- Theripeutical Chemistry Department
- Applied Organic Chemistry Department
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)
- Issue: Vol 86, No 12 (2016)
- Pages: 2785-2790
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/216936
- DOI: https://doi.org/10.1134/S1070363216120409
- ID: 216936
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Abstract
A new group of chiral linear 7-methyl-4-oxo-1,8-naphthyridine-3-carboxamides with incorporated peptide linkage have been synthesized via condensation of 1-ethyl-N-(1-hydrazinyl-3-methyl-1-oxobutan-2-yl)-7-methyl–4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide with various derivatives of sugar pentose, acetophenones and thiosemicarbazide. Structures of the products were elucidated by spectroscopic methods and chemical analysis. Antimicrobial properties of the synthesized compounds were tested.
About the authors
N. M. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy; Theripeutical Chemistry Department
Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
A. E. G. Amr
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy; Applied Organic Chemistry Department
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
M. A. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451
E. S. Nossier
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)
Email: nagykhalifa@hotmail.com
Egypt, Cairo
