Synthesis, Two-Photon Absorption, and Cellular Imaging of Two Curcumin Derivatives
- Authors: Zhang W.1, Zhou S.S.1,2, Si G.F.1, Wang J.F.1, Xu G.Y.2
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Affiliations:
- Department of Pharmacy
- Center of Modern Experimental Technology
- Issue: Vol 89, No 12 (2019)
- Pages: 2577-2583
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223254
- DOI: https://doi.org/10.1134/S1070363219120387
- ID: 223254
Cite item
Abstract
Two curcumin derivatives, 1,7-bis(4-bromoethyloxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (1) and 1,7-bis(4-bromobutyloxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (2), have been conveniently synthesized and their structures characterized by 1H NMR and mass spectra, and single crystal X-ray diffraction measurements. Single-photon and two-photon fluorescence properties have been studied. The calculated two-photon absorption cross-sections for both compounds by quantum chemical method are as high as 358 and 326 GM, respectively. Two-photon fluorescent imaging of MCF-7 cells labeled with the compound 1 indicates its potential application as a biological fluorescent probe.
About the authors
W. Zhang
Department of Pharmacy
Email: jiafeng_wang2002@163.com
China, Hefei, 230012
S. S. Zhou
Department of Pharmacy; Center of Modern Experimental Technology
Email: jiafeng_wang2002@163.com
China, Hefei, 230012; Hefei, 230039
G. F. Si
Department of Pharmacy
Email: jiafeng_wang2002@163.com
China, Hefei, 230012
J. F. Wang
Department of Pharmacy
Author for correspondence.
Email: jiafeng_wang2002@163.com
China, Hefei, 230012
G. Y. Xu
Center of Modern Experimental Technology
Email: jiafeng_wang2002@163.com
China, Hefei, 230039
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