Synthesis of New Fused Furo- and Thienopyridines

V. V. Dabaeva; M. R. Baghdasaryan; E. G. Paronikyan; R. A. Tamazyan; A. G. Ayvazyan; Sh. Sh. Dashyan

doi:10.1134/S1070363219120065

Synthesis of New Fused Furo- and Thienopyridines

Authors: Dabaeva V.V.¹, Baghdasaryan M.R.¹, Paronikyan E.G.¹, Tamazyan R.A.¹, Ayvazyan A.G.¹, Dashyan S.S.¹
Affiliations:
1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Issue: Vol 89, No 12 (2019)
Pages: 2364-2368
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/223189
DOI: https://doi.org/10.1134/S1070363219120065
ID: 223189

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Abstract

A method was developed for the synthesis of new fused derivatives of pyrano[4,3-b]thieno(furo)-pyridine, namely 8,8-dimethyl-11-(2-furyl)-7,10-dihydro-8H-pyrano[3″,4″:5′,6′]pyrido[3′,2′:4,5]thieno(furo)[3,2-d]- pyrimidine-4(3H)-ones, from 2,2-dimethyltetrahydropyran-4-one. Optimal conditions for carrying out the cyclization reaction of ethyl {7,7-dimethyl-4-(2-furyl-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridin-2-yl]oxy}acetate into the corresponding amino ester were determined.