Synthesis and Antimicrobial Activity of (E)-2-[(1-Substituted Phenyl-1H-1,2,3-triazol-4-yl)methylene]-2,3-dihydro-1H-inden-1-ones


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Abstract

A series of novel (E)-2-[(1-phenyl-1H-1,2,3-triazol-4-yl)methylene]-2,3-dihydro-1H-inden-1-one derivatives has been synthesized by condensation of 1-phenyl-1H-1,2,3-triazole-4-carbaldehydes with 2,3-dihydro-1H-inden-1-one. The synthesized compounds are characterized by 1H and 13C NMR, and mass spectrometry, and tested in vitro against four bacterial organism and two fungal organisms. The tests data demonstrate moderate to good activity of the compounds.

About the authors

M. K. Swamy

Department of Chemistry

Email: pallapothulavrao@gmail.com
India, Hyderabad, 500007

M. Swapna

Department of Chemistry

Email: pallapothulavrao@gmail.com
India, Hyderabad, 500007

T. Sandeep

Department of Chemistry

Email: pallapothulavrao@gmail.com
India, Hyderabad, 500007

P. Venkateswar Rao

Department of Chemistry

Author for correspondence.
Email: pallapothulavrao@gmail.com
India, Hyderabad, 500007

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