Double Arbuzov Reaction. Synthesis of Bis(ω-cyanoalkyl)phosphinic Acids
- Authors: Ragulin V.V.1
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Affiliations:
- Institute of Physiologically Active Substances of the Russian Academy of Sciences
- Issue: Vol 89, No 8 (2019)
- Pages: 1728-1730
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/223055
- DOI: https://doi.org/10.1134/S1070363219080292
- ID: 223055
Cite item
Abstract
A general method for the synthesis of symmetric bis(ω-cyanoalkyl)phosphinic acids from ammonium hypophosphite was proposed. The reaction of bis(trimethylsilyl)hypophosphite generated in situ with the ω-bromoalkylnitrile molecule according to the Arbuzov reaction and the subsequent silylation of the hydrophosphoryl intermediate leads to the formation of bis(trimethylsilyl)phosphonite. The latter reacts with the second ω-haloalkylnitrile molecule by the Arbuzov reaction with the formation of the second phosphorus-carbon bond.
About the authors
V. V. Ragulin
Institute of Physiologically Active Substances of the Russian Academy of Sciences
Author for correspondence.
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432