Synthesis of New Fused Thiopyridines and Their Reaction with Acetylacetone in the Presence of Mercury(II) Acetate
- Authors: Hobosyan N.G.1, Balyan K.V.1, Nersisyan H.S.1, Sargsyan H.B.1, Kobalyan V.M.1, Dashyan S.S.1, Nazaryan I.M.1, Paronikyan E.G.1
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Affiliations:
- Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
- Issue: Vol 89, No 8 (2019)
- Pages: 1586-1590
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223023
- DOI: https://doi.org/10.1134/S1070363219080073
- ID: 223023
Cite item
Abstract
The method of synthesis of fused thiopyridines via S-alkylation of the corresponding pyridine thiones with propargyl bromide has been elaborated. Fused enol tautomers have been obtained via the reaction of the prepared thiopropargyl pyridine compounds with acetylacetone in the presence of mercury(II) acetate followed by the reduction of intermediate organomercury compounds with alkali solution of sodium borohydride. Neurotropic activity of the synthesized compounds has been studied, and compounds with pronounced anticonvulsant activity have been identified.
About the authors
N. G. Hobosyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
K. V. Balyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
H. S. Nersisyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
H. B. Sargsyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
V. M. Kobalyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
Sh. Sh. Dashyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
I. M. Nazaryan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014
E. G. Paronikyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of the Republic of Armenia
Email: ninahobosyan@mail.ru
Armenia, pr. Azatutyan 26, Erevan, 0014