Synthesis, Structure, and Biological Activity of Coordination Compounds of Cobalt(II), Nickel(II), and Copper(II) with N-(Methoxyphenyl)-2-[(5-nitrofuryl)methylene]hydrazine Carbothioamides

Abstract

4-(2-Methoxyphenyl)-, 4-(3-methoxyphenyl)-, and 4-(4-memoxyphenyl)-2-[(5-mttofuryl)methylene]-hydrazine carboxamide (HL^1–3) react with hydrates of cobalt (nickel, copper) chloride (nitrate, acetate) with the formation of the M(HL^1–3)₂X₂ (M = Co²⁺, Ni²⁺, Cu²⁺; X = Cl⁻, NO₃₋) and M(L^1–3)₂ (M = Ni²⁺, Cu²⁺) coordination compounds. Structure of the obtained compounds has been studied by means of X-ray diffraction analysis. Their antimicrobial and antifungal activity towards a series of Staphylococcus aureus, Escherichia coli, and yeast-like fungi standard strains has been investigated.