Synthesis and Anticancer Evaluation of Amide Derivatives of 1,3,4-Oxadiazole Linked with Benzoxazole
- Authors: Ravinaik B.1, Ramachandran D.1, Rao M.V.2
-
Affiliations:
- Department of Chemistry
- Department of Chemistry, Dr. MRAR. PG Centre
- Issue: Vol 89, No 5 (2019)
- Pages: 1003-1008
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222914
- DOI: https://doi.org/10.1134/S1070363219050219
- ID: 222914
Cite item
Abstract
A novel series of amide 1,3,4-oxadiazole linked benzoxazole derivatives 12a–12j are synthesized and their anticancer activity is screened against four human cancer cell lines including A549 (Lung cancer), MCF7 (Breast cancer), A375 (Melanoma cancer), HT-29 (Colon cancer) using Combretastatin-A4 as a control drug. Among the synthesized compounds, 12c and 12g demonstrate potent anticancer activity against HT-29 cancer cell line with IC50 values of 0.018 and 0.093 µM, respectively, which is higher than the standard drug.
About the authors
B. Ravinaik
Department of Chemistry
Email: dittakavirc@gmail.com
India, Machilipatnam, Andhra Pradesh, 521001
D. Ramachandran
Department of Chemistry
Author for correspondence.
Email: dittakavirc@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510
M. V. Basaveswara Rao
Department of Chemistry, Dr. MRAR. PG Centre
Email: dittakavirc@gmail.com
India, Nuzvid, Andhra Pradesh, 521201
![](/img/style/loading.gif)