Synthesis and Anticancer Activity of 1,2,3-Triazole Fused N-Arylpyrazole Derivatives
- Authors: Lakkakula R.1, Roy A.1, Mukkanti K.2, Sridhar G.3
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Affiliations:
- GVK Biosciences Private Limited
- Department of Chemistry
- Organic and Biomolecular Chemistry Division
- Issue: Vol 89, No 4 (2019)
- Pages: 831-835
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222883
- DOI: https://doi.org/10.1134/S1070363219040315
- ID: 222883
Cite item
Abstract
A novel series of triazole derivatives 11a–11j is synthesized. Structures of the products are confirmed by 1H and 13C NMR, and mass spectral data. The anticancer activities of compounds 11a–11j are evaluated against three human cancer cell lines (MCF-7, A549, and A375) using the standard MTT assay in vitro, using doxorubicin as the positive control. All the compounds exhibit significant activity against cancer cell lines. The compounds 11a, 11d, 11e, 11g, and 11j demonstrate more potent activity than the positive control.
About the authors
R. Lakkakula
GVK Biosciences Private Limited
Email: sridhar1org@gmail.com
India, 28A, Nacharam, IDA-Mallapur, Hyderabad, Telangana, 500076
A. Roy
GVK Biosciences Private Limited
Author for correspondence.
Email: sridhar1org@gmail.com
India, 28A, Nacharam, IDA-Mallapur, Hyderabad, Telangana, 500076
K. Mukkanti
Department of Chemistry
Email: sridhar1org@gmail.com
India, Kukatpally, Hyderabad, Telangana, 500085
G. Sridhar
Organic and Biomolecular Chemistry Division
Email: sridhar1org@gmail.com
India, Hyderabad, 50010