Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts
- Authors: Gein V.L.1, Bobrovskaya O.V.1, Russkikh A.A.1, Novikova V.V.1, Gein O.N.1, Karpenko Y.N.1, Chashchina S.V.2, Dmitriev M.V.2, Yankin A.N.3
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Affiliations:
- Perm State Pharmaceutical Academy
- Perm National State Research University
- St. Petersburg State University
- Issue: Vol 89, No 4 (2019)
- Pages: 680-688
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222849
- DOI: https://doi.org/10.1134/S1070363219040078
- ID: 222849
Cite item
Abstract
The reaction of 4-aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.
About the authors
V. L. Gein
Perm State Pharmaceutical Academy
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
O. V. Bobrovskaya
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
A. A. Russkikh
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
V. V. Novikova
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
O. N. Gein
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
Yu. N. Karpenko
Perm State Pharmaceutical Academy
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
S. V. Chashchina
Perm National State Research University
Email: geinvl48@mail.ru
Russian Federation, ul. Bukireva 15, Perm, 614990
M. V. Dmitriev
Perm National State Research University
Email: geinvl48@mail.ru
Russian Federation, ul. Bukireva 15, Perm, 614990
A. N. Yankin
St. Petersburg State University
Email: geinvl48@mail.ru
Russian Federation, St. Petersburg, 199034