Synthesis of New Camphane-Type Amides: Potential Synthetic Adaptogenes

I. A. Novakov; R. V. Brunilin; G. M. Butov; A. A. Vernigora; M. B. Navrotskii; A. S. Yablokov; S. N. Voloboev

doi:10.1134/S1070363219030058

Synthesis of New Camphane-Type Amides: Potential Synthetic Adaptogenes

Authors: Novakov I.A.¹, Brunilin R.V.¹, Butov G.M.², Vernigora A.A.¹, Navrotskii M.B.¹, Yablokov A.S.¹, Voloboev S.N.³
Affiliations:
1. Volgograd State Technical University
2. Volzhskii Polytechnic Institute
3. LLC LUKOIL-Volgogradneftepererabotka
Issue: Vol 89, No 3 (2019)
Pages: 399-404
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222779
DOI: https://doi.org/10.1134/S1070363219030058
ID: 222779

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Abstract

A significant effect of the steric factor on the activity of 3,5-dimethyl-1H-pyrazolide as an acylating agent has been found using the example of acylation of camphane-type monoamines. The predominant contribution of the catalytic hydrogenation as a component of the Schwenk-Papa reaction has been confirmed by the synthesis of 4-chlorobenzoyl derivatives.