Methyl Trifluoropyruvate in Cyclocondensation Reactions with  N -Substituted Ureas

V. B. Sokolov; A. Yu. Aksinenko

doi:10.1134/S1070363219010286

Methyl Trifluoropyruvate in Cyclocondensation Reactions with N-Substituted Ureas

Authors: Sokolov V.B.¹, Aksinenko A.Y.¹
Affiliations:
1. Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Issue: Vol 89, No 1 (2019)
Pages: 153-156
Section: Letters to the Editor
URL: https://journals.rcsi.science/1070-3632/article/view/222727
DOI: https://doi.org/10.1134/S1070363219010286
ID: 222727

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Abstract
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Abstract

The transformations of methyl trifluoropyruvate in cyclocondensation reactions with N-substituted ureas, leading to 3-substituted 5-hydroxy- or 5-methoxy-5-trifluoromethylimidazolidine-2,4-diones, were studied. The possibility of using 5-hydroxy-3-(prop-2-in-1-yl)-5-trifluoromethylimidazolidine-2,4-dione for modifying phenothiazine with a copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition was shown.

Keywords

methyl trifluoropyruvate, N-substituted ureas, 5-trifluoromethylimidazolidine-2,4-diones, phenothiazine, 1,3-dipolar cycloaddition

About the authors

V. B. Sokolov

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432

A. Yu. Aksinenko