Synthesis, Characterization, and Anticancer Activity of Some Thiazole and Imidazolidine Derivatives Containing Pyridine Moiety
- Authors: Al-Saleem M.S.1, El-Shenawy A.I.1, Abd El-Moneim M.1, El-Sayed E.H.1
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Affiliations:
- Department of Chemistry, College of Science
- Issue: Vol 88, No 12 (2018)
- Pages: 2675-2679
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222622
- DOI: https://doi.org/10.1134/S1070363218120320
- ID: 222622
Cite item
Abstract
5-Phenyl-2-[(6-acetylpyridine-2-ylethylidene)hydrazino]thiazole 4 and 1-[(6-acetylpyrid-ine-2-ylethylidene)amino]-2-thioxoimidazolidine-4-one 6 are synthesized by cyclization of 1-[1-(6-acetylpyridin-2- yl)ethylidene]thiosemicarbazide 2 with phenacyl(ω)bromide or ethyl chloroacetate in the presence of fused sodium acetate. Reaction of compounds 2, 4, and 6 with acetic anhydride gives N-triacetyl derivative 3 and N-acetyl derivatives 5 and 7. Treatment of compound 6 with 4-methoxy benzaldehyde yields the corresponding carbanol derivative 8. Structures of the synthesized heterocyclic compounds are characterized by EI-MS and NMR spectroscopy. Antitumor activity of compounds 4, 6, 8, and 9 is evaluated against human breast carcinoma cell line (MCF-7).
Keywords
About the authors
M. S. Al-Saleem
Department of Chemistry, College of Science
Email: aielshenawy@gmail.com
Saudi Arabia, Riyadh, 11671
A. I. El-Shenawy
Department of Chemistry, College of Science
Author for correspondence.
Email: aielshenawy@gmail.com
Egypt, Benha, 13518
M. Abd El-Moneim
Department of Chemistry, College of Science
Email: aielshenawy@gmail.com
Egypt, Port Said
E. H. El-Sayed
Department of Chemistry, College of Science
Email: aielshenawy@gmail.com
Egypt, Port Said
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