Email this article Pyran Derivatives: Anti-Breast Cancer Activity and Docking Study
- Authors: Han H.1, Zhang Z.2, Zhang J.3, Zhang B.3
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Affiliations:
- Inner Mongolia University For The Nationalities
- Nursing Department
- The First Affiliated Hospital of Inner Mongolia University For The Nationalities
- Issue: Vol 88, No 12 (2018)
- Pages: 2664-2668
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222614
- DOI: https://doi.org/10.1134/S1070363218120307
- ID: 222614
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Abstract
Four novel pyran derivatives 1–4 are synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray data. Anticancer activity of the compounds is tested against four human breast cancer cells (HCC1937, HCC70, MDA-MB-436, and BT474) by MTT assay. Molecular docking study supports the biological assay data and suggests that compound 2 has a potential as an anticancer agent.
Keywords
About the authors
H. Han
Inner Mongolia University For The Nationalities
Email: bin_zhang666@126.com
China, Tongliao, Inner Mongolia Autonomous Region
Z.-F. Zhang
Nursing Department
Email: bin_zhang666@126.com
China, Tongliao, Inner Mongolia Autonomous Region
J.-F. Zhang
The First Affiliated Hospital of Inner Mongolia University For The Nationalities
Email: bin_zhang666@126.com
China, Tongliao, Inner Mongolia Autonomous Region
B. Zhang
The First Affiliated Hospital of Inner Mongolia University For The Nationalities
Author for correspondence.
Email: bin_zhang666@126.com
China, Tongliao, Inner Mongolia Autonomous Region
