Design, Synthesis, and Anticancer Evaluation of Tetrazole-Fused Benzoxazole Derivatives as Tubulin Binding Agents
- Authors: Ravikumar P.1,2, Raolji G.S.2, Venkata Sastry K.3, Kalidasu S.1,2, Balaaraju T.4
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Affiliations:
- Department of Chemistry
- GVK Biosciences Private Limited, Nacharam, IDA Mallapur
- CMR College of Pharmacy, Medchal
- Department of Chemistry, School of Science
- Issue: Vol 88, No 10 (2018)
- Pages: 2183-2189
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222499
- DOI: https://doi.org/10.1134/S1070363218100250
- ID: 222499
Cite item
Abstract
A novel series of tetrazole fused benzoxazole derivatives 9a–9j are synthesized, and their structures are characterized by 1H and 13C NMR, and mass spectra. The compounds 9a, 9b, 9g, 9h, and 9j demonstrate the highest activity. The compounds 9b and 9g exhibit good anticancer activity, in particular against MCF7, Hop62, and A-549 cell lines with the range of GI50 values from <0.1 to 4.56 μM. Molecular docking study is carried out for the compounds 9a–9j, according to which the compound 9b forms one hydrogen bond with THR766 with the highest docking score (–7.33). This indicates that 9b is effeciently binging to tubulin site.
About the authors
P. Ravikumar
Department of Chemistry; GVK Biosciences Private Limited, Nacharam, IDA Mallapur
Author for correspondence.
Email: ravipolothi@gmail.com
India, Hyderabad, Telangana, 500082; Hyderabad, Telangana, 500076
G. S. B. Raolji
GVK Biosciences Private Limited, Nacharam, IDA Mallapur
Email: ravipolothi@gmail.com
India, Hyderabad, Telangana, 500076
K. Venkata Sastry
CMR College of Pharmacy, Medchal
Email: ravipolothi@gmail.com
India, Hyderabad, Telangana, 501401
S. Kalidasu
Department of Chemistry; GVK Biosciences Private Limited, Nacharam, IDA Mallapur
Email: ravipolothi@gmail.com
India, Hyderabad, Telangana, 500082; Hyderabad, Telangana, 500076
T. Balaaraju
Department of Chemistry, School of Science
Email: ravipolothi@gmail.com
India, Hyderabad, Telangana, 502329
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