N-Propargyl-α-aminophosphonates in 1,3-Dipolar Cycloaddition with Azide-Containing Pharmacophores
- Authors: Sokolov V.B.1, Aksinenko A.Y.1
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Affiliations:
- Institute of Physiologically Active Substances of the Russian Academy of Sciences
- Issue: Vol 88, No 9 (2018)
- Pages: 1922-1926
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222432
- DOI: https://doi.org/10.1134/S107036321809027X
- ID: 222432
Cite item
Abstract
Some transformations of N-propargyl-α-aminophosphonates synthesized by the Kubachnik–Fields reaction were studied in copper-catalyzed 1,3-dipolar cycloaddition with azide-containing pharmacophores (phenothiazine, tetrahydrocarbazole, carbazole, and 3,5-dimethyl-1-aminoadamantane) leading to the formation of the corresponding 1,4-substituted 1,2,3-triazoles and allowing the introduction of a diethoxyphosphoryl fragment into the molecules of potential neuroprotectors.
About the authors
V. B. Sokolov
Institute of Physiologically Active Substances of the Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Substances of the Russian Academy of Sciences
Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
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