Email this article One-Pot Four Component Synthesis of 3-Amino-1-(1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine Derivatives Mediated by [DBUH][OAc]
- Authors: Jeevan Raghavendra G.1, Siddaiah V.1
-
Affiliations:
- Department of Organic Chemistry, Foods, Drug and Water, College of Science and Technology
- Issue: Vol 88, No 9 (2018)
- Pages: 1892-1898
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222424
- DOI: https://doi.org/10.1134/S1070363218090219
- ID: 222424
Cite item
Open Access
Access granted
Subscription Access
Abstract
One-pot, four component, green, and efficient synthesis of 3-amino-1-(5-nitro-1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine derivatives by reaction of phthalic anhydride with hydrazine hydrate, 5-nitro-1H-indole-3-carboxaldehyde–indole-3-carboxaldehydes and malononitrile–ethyl cyanoacetate in the presence of [DBUH][OAc] at 60–65°C is developed. The method is characterized by short reaction time, high yields, and purity of products formed.
Keywords
About the authors
G. Jeevan Raghavendra
Department of Organic Chemistry, Foods, Drug and Water, College of Science and Technology
Author for correspondence.
Email: jeevan.gutala@gmail.com
India, Visakhapatnam, Andhra Pradesh, 530003
V. Siddaiah
Department of Organic Chemistry, Foods, Drug and Water, College of Science and Technology
Email: jeevan.gutala@gmail.com
India, Visakhapatnam, Andhra Pradesh, 530003
