The First 1-Hydroxypropylidenebisphosphonic Acid with 1,8-Naphthyridinone Substituent: Synthesis and Structure

G. V. Bodrin; M. P. Pasechnik; A. G. Matveeva; R. R. Aysin; S. V. Matveev; E. I. Goryunov; T. V. Strelkova; V. K. Brel

doi:10.1134/S1070363218090050

The First 1-Hydroxypropylidenebisphosphonic Acid with 1,8-Naphthyridinone Substituent: Synthesis and Structure

Authors: Bodrin G.V.¹, Pasechnik M.P.¹, Matveeva A.G.¹, Aysin R.R.¹, Matveev S.V.¹, Goryunov E.I.¹, Strelkova T.V.¹, Brel V.K.¹
Affiliations:
1. Nesmeyanov Institute of Organoelement Compounds
Issue: Vol 88, No 9 (2018)
Pages: 1792-1799
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222401
DOI: https://doi.org/10.1134/S1070363218090050
ID: 222401

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Abstract

1-Hydroxy-3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propylidenebisphosphonic acid has been synthesized. The structure of the acid and its precursors synthesized for the first time, 3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propionic acid and the corresponding methyl ester, in the solid state and in the DMSO solution has been elucidated by means of vibrational (IR and Raman) and multinuclear (¹H, ¹³C, and ³¹P) NMR spectroscopy.